Cardiomyocyte MEA Data Analysis (CardioMDA) – A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes
نویسندگان
چکیده
منابع مشابه
Cardiomyocyte MEA Data Analysis (CardioMDA) – A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes
Cardiac safety pharmacology requires in-vitro testing of all drug candidates before clinical trials in order to ensure they are screened for cardio-toxic effects which may result in severe arrhythmias. Micro-electrode arrays (MEA) serve as a complement to current in-vitro methods for drug safety testing. However, MEA recordings produce huge volumes of data and manual analysis forms a bottleneck...
متن کاملNovel Analysis Software for Detecting and Classifying Ca2+ Transient Abnormalities in Stem Cell-Derived Cardiomyocytes
Comprehensive functioning of Ca2+ cycling is crucial for excitation-contraction coupling of cardiomyocytes (CMs). Abnormal Ca2+ cycling is linked to arrhythmogenesis, which is associated with cardiac disorders and heart failure. Accordingly, we have generated spontaneously beating CMs from induced pluripotent stem cells (iPSC) derived from patients with catecholaminergic polymorphic ventricular...
متن کاملNovel Analysis Software for Detecting and Classifying Ca Transient Abnormalities in Stem Cell-Derived Cardiomyocytes
Comprehensive functioning of Ca cycling is crucial for excitation–contraction coupling of cardiomyocytes (CMs). Abnormal Ca cycling is linked to arrhythmogenesis, which is associated with cardiac disorders and heart failure. Accordingly, we have generated spontaneously beating CMs from induced pluripotent stem cells (iPSC) derived from patients with catecholaminergic polymorphic ventricular tac...
متن کاملInduced Pluripotent Stem Cell–Derived Cardiomyocytes: A New and Versatile Human In Vitro Cardiomyocyte Model
Induced Pluripotent Stem Cell–Derived Cardiomyocytes: A New and Versatile Human In Vitro Cardiomyocyte Model Recent advances in genomics and molecular medicine promise to revolutionize human health by enabling more precise prediction, prevention, and treatment of cardiovascular diseases on an individual level. This precision medicine approach is based on the ability to diagnose and stratify pat...
متن کاملStem Cell–Derived Cardiomyocytes Demonstrate Arrhythmic Potential
Background—Cardiomyocytes (CMs) derived from pluripotent embryonic stem cells (ESCs) and embryonal carcinoma cells (ECCs) have some but not all characteristics of adult myocytes. ESCs have shown the ability to engraft in areas of myocardial damage, which suggests their use in cell transplantation therapy for cardiomyopathy. We studied the arrhythmogenic properties of CMs differentiated from mou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0073637